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Correlation between manifestations of digoxin toxicity and serum digoxin, calcium, potassium, and magnesium concentrations and arterial pH.

机译:地高辛毒性表现与血清地高辛,钙,钾,镁浓度和动脉pH的相关性。

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摘要

In 18 patients with gastrointestinal manifestations of digoxin toxicity the mean serum digoxin concentration (+/- SEM) was 3.16 micrograms/l (+/- 0.25), the calcium to potassium ratio 0.31 (+/- 0.01), and the mean arterial pH 7.406 (+/- 0.017). In contrast 19 patients with digoxin induced automaticity had a mean serum digoxin concentration of 1.24 micrograms/l (+/- 0.15; p less than 0.001), a calcium to potassium ratio of 0.38 (+/- 0.01; p less than 0.01), and an arterial pH of 7.498 (+/- 0.008; p less than 0.001). Eight out of 13 patients with digoxin induced cardiotoxicity had serum concentrations of the drug within the therapeutic range (0.8-2.0 micrograms/l). The calcium to potassium ratio, however, was lower than in the patients with automaticity (0.31 +/- 0.02; p less than 0.01) and the arterial pH was 7.370 (+/- 0.033; p less than 0.05). Serum magnesium concentrations were similar in all groups. In this study patients with digoxin induced gastrointestinal symptoms had high serum concentrations of the drug, whereas those with drug induced automaticity had therapeutic concentrations. This second group, however, was identified by their higher calcium to potassium ratios and higher pH values.
机译:在18名具有地高辛毒性胃肠道表现的患者中,平均血清地高辛浓度(+/- SEM)为3.16微克/升(+/- 0.25),钙钾比为0.31(+/- 0.01)和平均动脉pH 7.406(+/- 0.017)。与此相反,地高辛诱导的自动性的19例患者的平均血清地高辛浓度为1.24微克/升(+/- 0.15; p小于0.001),钙钾比为0.38(+/- 0.01; p小于0.01),动脉pH为7.498(+/- 0.008; p小于0.001)。 13例由地高辛引起的心脏毒性患者中,有8例的药物血清浓度在治疗范围内(0.8-2.0微克/升)。然而,钙和钾的比例低于自动患者(0.31 +/- 0.02; p小于0.01),动脉pH为7.370(+/- 0.033; p小于0.05)。所有组的血清镁浓度相似。在这项研究中,具有地高辛诱导的胃肠道症状的患者具有较高的药物血清浓度,而具有药物诱导的自发性的患者具有治疗浓度。然而,第二组被发现具有较高的钙钾比和较高的pH值。

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